Healthspan

Assembled from 19 blocks · 2 evidence · 10 related

1. Story
2. The span of life spent free of significant chronic disease and disability, as distinct from lifespan, the span of life. The distinction is the whole subject: an intervention that adds years of frailty and an intervention that removes years of frailty can produce identical life expectancy statistics. The operational proxy in international statistics is healthy life expectancy (HALE), computed by weighting years lived by disability prevalence and severity; the WHO reported global life expectancy of about 73.3 years and HALE of about 63.7 years for 2019, and about 71.4 and 61.9 respectively for 2021 after the pandemic. The roughly decade-long gap between the two has been broadly stable or slowly widening, which is evidence against Fries's strong compression hypothesis and for the rival view that added years are partly added morbidity. Healthspan has no agreed clinical definition, no single measurement instrument and no regulatory endpoint, which is why almost nothing in the field is tested against it directly.
3. Knowledge
4. Healthspan
5. The missing surrogate endpoint for ageing
6. Connections
7. The missing surrogate endpoint for ageing
8. Fries proposes the compression of morbidity
9. The pandemic erases a decade of life expectancy gains
10. Healthspan
11. Senolytics
12. TAME — Targeting Aging with Metformin
13. Epigenetic clocks
14. TAME is proposed as the first trial with an ageing endpoint
15. Senolytics reach human patients for the first time
16. Caloric restriction is reported to slow a pace-of-ageing measure
17. Evidence
18. Supports the paired life expectancy and healthy life expectancy figures and the pandemic-era reversal. V55 verification basis: the report was NOT retrieved; the specific edition carrying the 2021 values must be identified and the figures checked by the curator.
19. Supports the compression-of-morbidity hypothesis as originally stated. V55 verification basis: not retrieved in this session; the paper is cited for the hypothesis, not as evidence that it holds.