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CALERIE reports two-year results in humans

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The only randomised controlled trial of sustained caloric restriction in healthy non-obese adults reports its two-year outcomes: the intervention is feasible but achieved restriction falls well short of the twenty-five percent target, cardiometabolic risk markers improve, and bone density and lean mass decline. No lifespan inference is possible or claimed.

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Assembled from 22 blocks · 1 evidence · 15 related

  1. Story
  2. The only randomised controlled trial of sustained caloric restriction in healthy non-obese adults reports its two-year outcomes: the intervention is feasible but achieved restriction falls well short of the twenty-five percent target, cardiometabolic risk markers improve, and bone density and lean mass decline. No lifespan inference is possible or claimed.
  3. Knowledge
  4. Caloric restriction
  5. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
  6. CALERIE reports two-year results in humans
  7. Connections
  8. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
  9. Caloric restriction
  10. Caloric restriction
  11. Epigenetic clocks
  12. CALERIE reports two-year results in humans
  13. Caloric restriction is reported to slow a pace-of-ageing measure
  14. Model organism lifespan research
  15. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
  16. Rapamycin
  17. Caloric restriction extends rodent lifespan
  18. Wisconsin reports that caloric restriction reduces age-related mortality in rhesus monkeys
  19. The NIA rhesus study reports no significant survival benefit
  20. CALERIE reports two-year results in humans
  21. Evidence
  22. Supports the feasibility, achieved-restriction shortfall and cardiometabolic outcomes of the only randomised trial of sustained caloric restriction in healthy non-obese humans. V55 verification basis: not retrieved; participant numbers and achieved restriction percentage are recalled and must be checked.
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/atlas?object=EVT_LGV_CALERIE_RESULTS_2015&experience=EVT_LGV_CALERIE_RESULTS_2015