The NIA Interventions Testing Program begins

Assembled from 21 blocks · 1 evidence · 16 related

1. Story
2. The United States National Institute on Aging establishes a programme to test candidate lifespan-extending compounds in genetically heterogeneous mice at three independent sites under a common protocol. It exists because single-laboratory, single-strain mouse lifespan results had proved poorly reproducible, and its most valuable output has been its list of failures.
3. Knowledge
4. Model organism lifespan research
5. NIA Interventions Testing Program
6. The NIA Interventions Testing Program begins
7. Connections
8. NIA Interventions Testing Program
9. Model organism lifespan research
10. Rapamycin
11. Model organism lifespan research
12. The NIA Interventions Testing Program begins
13. Rapamycin extends mouse lifespan when started in late life
14. The hallmarks of ageing
15. Caenorhabditis elegans
16. Caloric restriction
17. NIA Interventions Testing Program
18. A single-gene mutation doubles nematode lifespan
19. The NIA Interventions Testing Program begins
20. Evidence
21. Supports the late-life lifespan extension by rapamycin replicated across the Interventions Testing Program's three sites. V55 verification basis: not retrieved; the specific percentage extensions and the sex difference are unchecked and are therefore not quoted numerically in the objects citing this record.