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Caloric restriction extends rodent lifespan

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Clive McCay, Mary Crowell and Leonidas Maynard at Cornell report that rats fed a restricted but nutritionally adequate diet from a young age live substantially longer than freely fed controls. It is the founding result of experimental gerontology and, ninety years later, still the most reproducible one.

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Assembled from 16 blocks · 1 evidence · 13 related

  1. Story
  2. Clive McCay, Mary Crowell and Leonidas Maynard at Cornell report that rats fed a restricted but nutritionally adequate diet from a young age live substantially longer than freely fed controls. It is the founding result of experimental gerontology and, ninety years later, still the most reproducible one.
  3. Knowledge
  4. Caloric restriction
  5. Caloric restriction extends rodent lifespan
  6. Connections
  7. Caloric restriction
  8. Model organism lifespan research
  9. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
  10. Rapamycin
  11. Caloric restriction extends rodent lifespan
  12. Wisconsin reports that caloric restriction reduces age-related mortality in rhesus monkeys
  13. The NIA rhesus study reports no significant survival benefit
  14. CALERIE reports two-year results in humans
  15. Evidence
  16. Supports the founding demonstration that dietary restriction extends rodent lifespan. V55 verification basis: not retrieved in this session.
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