CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)

Assembled from 25 blocks · 2 evidence · 19 related

1. Story
2. The National Institute on Aging's multi-site randomised controlled trial of sustained caloric restriction in healthy non-obese adults — the only such trial that exists. Its second phase randomised roughly two hundred participants to a target twenty-five percent restriction or ad libitum eating for two years; the achieved restriction was closer to twelve percent, which is itself an important finding about what humans will actually sustain. Reported effects included improvements in cardiometabolic risk markers, blood pressure and inflammatory markers, alongside reductions in bone mineral density and lean mass whose long-term significance is unclear. A 2023 reanalysis of stored samples reported a small slowing of the DunedinPACE pace-of-ageing measure without significant effects on first-generation epigenetic clocks. The trial cannot address lifespan: no human caloric restriction trial ever will, because the required follow-up exceeds the working life of the investigators.
3. Knowledge
4. Caloric restriction
5. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
6. Epigenetic clocks
7. Connections
8. Caloric restriction
9. Epigenetic clocks
10. CALERIE reports two-year results in humans
11. Caloric restriction is reported to slow a pace-of-ageing measure
12. Model organism lifespan research
13. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
14. Rapamycin
15. Caloric restriction extends rodent lifespan
16. Wisconsin reports that caloric restriction reduces age-related mortality in rhesus monkeys
17. The NIA rhesus study reports no significant survival benefit
18. CALERIE reports two-year results in humans
19. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
20. The missing surrogate endpoint for ageing
21. The multi-tissue epigenetic clock is published
22. Caloric restriction is reported to slow a pace-of-ageing measure
23. Evidence
24. Supports the feasibility, achieved-restriction shortfall and cardiometabolic outcomes of the only randomised trial of sustained caloric restriction in healthy non-obese humans. V55 verification basis: not retrieved; participant numbers and achieved restriction percentage are recalled and must be checked.
25. Supports the reported slowing of the DunedinPACE pace-of-ageing measure under caloric restriction, without significant effects on first-generation epigenetic clocks. V55 verification basis: not retrieved; the effect size is deliberately described qualitatively because the producer could not confirm the figure.