NIA Interventions Testing Program

Assembled from 22 blocks · 1 evidence · 16 related

1. Story
2. A United States National Institute on Aging programme, running since 2004, that tests candidate lifespan-extending compounds in genetically heterogeneous mice simultaneously at three independent sites, with a common protocol and pre-specified analysis. Its design is a direct response to the field's reproducibility problem: most published mouse lifespan results come from a single laboratory using a single inbred strain, and effects that look large under those conditions frequently disappear when the genetic background, the diet or the animal facility changes. The programme has confirmed a small number of compounds — rapamycin most convincingly — and has failed to confirm a considerably larger number of widely promoted ones, including several sold as human supplements. Its negative results are the more valuable part of the record and the part least reported.
3. Knowledge
4. Model organism lifespan research
5. Rapamycin
6. NIA Interventions Testing Program
7. Connections
8. Rapamycin
9. Model organism lifespan research
10. The NIA Interventions Testing Program begins
11. Rapamycin extends mouse lifespan when started in late life
12. Caloric restriction
13. NIA Interventions Testing Program
14. Rapamycin extends mouse lifespan when started in late life
15. The hallmarks of ageing
16. Caenorhabditis elegans
17. Caloric restriction
18. NIA Interventions Testing Program
19. A single-gene mutation doubles nematode lifespan
20. The NIA Interventions Testing Program begins
21. Evidence
22. Supports the late-life lifespan extension by rapamycin replicated across the Interventions Testing Program's three sites. V55 verification basis: not retrieved; the specific percentage extensions and the sex difference are unchecked and are therefore not quoted numerically in the objects citing this record.