Ogliastra and the Nuoro highlands, Sardinia

Assembled from 14 blocks · 2 evidence · 8 related

1. Story
2. A mountainous, historically isolated and comparatively poor area of eastern Sardinia, and the first region to be labelled a blue zone. Poulain, Pes and colleagues reported in the AKEA study of 2004 an unusually high density of male centenarians, and an unusual feature: a male-to-female centenarian ratio close to one, where the ratio elsewhere is typically one to four or five in women's favour. That anomaly is the strongest and the weakest part of the case — strongest because it is not what any ordinary demographic bias would produce, weakest because it is exactly the kind of extreme ratio that small-population noise or record error can generate. The population is genetically distinctive, with high frequencies of certain variants owing to long isolation, which has made it attractive for genetic studies of longevity; those studies have not identified a variant that accounts for the pattern.
3. Knowledge
4. Blue Zones
5. Ogliastra and the Nuoro highlands, Sardinia
6. Connections
7. Blue Zones
8. Maximum human lifespan
9. Okinawa
10. Ogliastra and the Nuoro highlands, Sardinia
11. Analyses of extreme-age records indicating clerical error and pension fraud as drivers of reported longevity hotspots
12. Evidence
13. Supports the identification of the Sardinian longevity area and the origin of the blue-zone designation. V55 verification basis: not retrieved; the reported male-to-female centenarian ratio is recalled and must be checked.
14. Cited to document the record-quality critique of blue zones and supercentenarian data. V55 verification basis: not retrieved; the exact preprint title, its version history and whether any version has since been peer-reviewed and published are all unchecked, which is why this record is flagged as a preprint.