AlphaFold2 is assessed blind at CASP14
At the fourteenth Critical Assessment of Structure Prediction, AlphaFold2 produced predictions against sequences whose experimentally determined structures had been solved but withheld, and was scored by independent assessors. The median domain GDT_TS is reported at 92.4, including on the free-modelling targets where no related structure was available to copy from — a level the assessment community described as competitive with experimental determination for most targets. The evidential design is the point: the claimant did not choose the targets, could not have trained on the answers, and did not do the scoring.
Observed — measured or witnessed, with the observation cited.
Subjects
- AlphaFold · technology system · not located
- CASP — Critical Assessment of Structure Prediction · institution · not located
- John Jumper · person · United States · not located
- Google DeepMind · company · United Kingdom · not located
Evidence
Verified — Every field is supported by a cited authoritative source.
Highly accurate protein structure prediction with AlphaFold
AlphaFold2 predicts protein structure from sequence at accuracy competitive with experimental determination for most targets, as assessed blind at CASP14 in 2020, where predictions are reported to have achieved a median domain GDT_TS of 92.4 including on free-modelling targets. V55 verification basis: the paper was NOT fetched — nature.com is blocked to this session — but search results carried the title, journal, volume 596 and pages 583–589 and attributed them to this paper, and carried the CASP14 accuracy characterisation. The 92.4 median GDT_TS figure is attributed in retrieved summaries to the CASP14 assessment literature rather than to this paper, and a curator should confirm which document reports it before it is quoted as the paper's own statistic.
Nature (Springer Nature) · 2021-07 · Verified
Jumper, J. et al., Nature 596, 583–589 (2021); https://www.nature.com/articles/s41586-021-03819-2 (PubMed 34265844)
Recorded on AlphaFold
- AlphaGo defeats Lee Sedol in Seoul
- AlphaFold2 is assessed blind at CASP14
- AlphaFold2 is published and the database opens
- The AlphaFold database expands to over 200 million structures
- GNoME is announced as 2.2 million new crystal structures
- The Nobel Prize in Chemistry recognises protein structure prediction
- GenCast is published with a like-for-like comparison against an operational ensemble
Related
Related because they share a subject in the Atlas — never because the text looks similar.
- The Nobel Prize in Chemistry recognises protein structure prediction · 2024-10
- GenCast is published with a like-for-like comparison against an operational ensemble · 2024-12
- GNoME is announced as 2.2 million new crystal structures · 2023-11
- The AlphaFold database expands to over 200 million structures · 2022-07-28
- AlphaFold2 is published and the database opens · 2021-07
- AlphaGo defeats Lee Sedol in Seoul · 2016-03-09 to 2016-03-15