Caloric restriction is reported to slow a pace-of-ageing measure

Assembled from 28 blocks · 1 evidence · 16 related

1. Story
2. A reanalysis of stored CALERIE samples reports that two years of caloric restriction produced a small slowing of the DunedinPACE pace-of-ageing measure, without significant effects on first-generation epigenetic clocks. It is the closest thing to a randomised human result on a biological-ageing measure that exists — and it also demonstrates the problem, because nobody can yet say what a two or three percent change in that measure is worth in years of health.
3. Knowledge
4. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
5. Epigenetic clocks
6. The missing surrogate endpoint for ageing
7. Caloric restriction is reported to slow a pace-of-ageing measure
8. Connections
9. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
10. Epigenetic clocks
11. The missing surrogate endpoint for ageing
12. Caloric restriction
13. Epigenetic clocks
14. CALERIE reports two-year results in humans
15. Caloric restriction is reported to slow a pace-of-ageing measure
16. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
17. The missing surrogate endpoint for ageing
18. The multi-tissue epigenetic clock is published
19. Caloric restriction is reported to slow a pace-of-ageing measure
20. Healthspan
21. Senolytics
22. TAME — Targeting Aging with Metformin
23. Epigenetic clocks
24. TAME is proposed as the first trial with an ageing endpoint
25. Senolytics reach human patients for the first time
26. Caloric restriction is reported to slow a pace-of-ageing measure
27. Evidence
28. Supports the reported slowing of the DunedinPACE pace-of-ageing measure under caloric restriction, without significant effects on first-generation epigenetic clocks. V55 verification basis: not retrieved; the effect size is deliberately described qualitatively because the producer could not confirm the figure.