Caloric restriction is reported to slow a pace-of-ageing measure

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A reanalysis of stored CALERIE samples reports that two years of caloric restriction produced a small slowing of the DunedinPACE pace-of-ageing measure, without significant effects on first-generation epigenetic clocks. It is the closest thing to a randomised human result on a biological-ageing measure that exists — and it also demonstrates the problem, because nobody can yet say what a two or three percent change in that measure is worth in years of health.

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