The hallmarks of ageing are formalised
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López-Otín, Blasco, Partridge, Serrano and Kroemer publish nine candidate processes in Cell, each required to manifest with age, to accelerate ageing when worsened and to retard it when improved. The paper becomes the field's common vocabulary; a 2023 revision expands the list to twelve.
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Connections · 2
- The hallmarks of ageingconcerns
- Cellular senescenceconcerns
Assembled narrative · 1
Assembled from 19 blocks · 1 evidence · 12 related
- Story
- López-Otín, Blasco, Partridge, Serrano and Kroemer publish nine candidate processes in Cell, each required to manifest with age, to accelerate ageing when worsened and to retard it when improved. The paper becomes the field's common vocabulary; a 2023 revision expands the list to twelve.
- Knowledge
- Cellular senescence
- The hallmarks of ageing
- The hallmarks of ageing are formalised
- Connections
- The hallmarks of ageing
- Cellular senescence
- Cellular senescence
- Model organism lifespan research
- The hallmarks of ageing are formalised
- The hallmarks of ageing
- Senolytics
- Human diploid cells are shown to have a finite replicative capacity
- The hallmarks of ageing are formalised
- The first senolytic drugs are identified
- Evidence
- Supports the hallmark framework, its three inclusion criteria and the expansion from nine to twelve hallmarks. V55 verification basis: neither paper was retrieved; the enumerated hallmark list must be checked against the originals.
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