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Rapamycin extends mouse lifespan when started in late life

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The Interventions Testing Program reports in Nature that rapamycin fed from about twenty months of age extends median and maximal lifespan in genetically heterogeneous mice at all three test sites. Starting the drug in middle-to-old age and still seeing an effect is what makes the result unusual and what made it the field's most cited pharmacological finding.

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Assembled from 18 blocks · 1 evidence · 12 related

  1. Story
  2. The Interventions Testing Program reports in Nature that rapamycin fed from about twenty months of age extends median and maximal lifespan in genetically heterogeneous mice at all three test sites. Starting the drug in middle-to-old age and still seeing an effect is what makes the result unusual and what made it the field's most cited pharmacological finding.
  3. Knowledge
  4. Rapamycin
  5. NIA Interventions Testing Program
  6. Rapamycin extends mouse lifespan when started in late life
  7. Connections
  8. Rapamycin
  9. NIA Interventions Testing Program
  10. Caloric restriction
  11. NIA Interventions Testing Program
  12. Rapamycin extends mouse lifespan when started in late life
  13. Rapamycin
  14. Model organism lifespan research
  15. The NIA Interventions Testing Program begins
  16. Rapamycin extends mouse lifespan when started in late life
  17. Evidence
  18. Supports the late-life lifespan extension by rapamycin replicated across the Interventions Testing Program's three sites. V55 verification basis: not retrieved; the specific percentage extensions and the sex difference are unchecked and are therefore not quoted numerically in the objects citing this record.
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/atlas?object=EVT_LGV_ITP_RAPAMYCIN_2009&experience=EVT_LGV_ITP_RAPAMYCIN_2009