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A single-gene mutation doubles nematode lifespan

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Cynthia Kenyon's laboratory reports that C. elegans carrying a mutation in daf-2, the insulin/IGF-1 receptor homologue, live more than twice as long as wild type and remain active, and that the extension requires the transcription factor daf-16. Ageing becomes a genetics problem, and the pathway turns out to be conserved into mammals.

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Assembled narrative · 1

Assembled from 24 blocks · 1 evidence · 16 related

  1. Story
  2. Cynthia Kenyon's laboratory reports that C. elegans carrying a mutation in daf-2, the insulin/IGF-1 receptor homologue, live more than twice as long as wild type and remain active, and that the extension requires the transcription factor daf-16. Ageing becomes a genetics problem, and the pathway turns out to be conserved into mammals.
  3. Knowledge
  4. Model organism lifespan research
  5. Caenorhabditis elegans
  6. Cynthia Kenyon
  7. A single-gene mutation doubles nematode lifespan
  8. Connections
  9. Cynthia Kenyon
  10. Cynthia Kenyon
  11. Caenorhabditis elegans
  12. Model organism lifespan research
  13. A single-gene mutation doubles nematode lifespan
  14. A single-gene mutation doubles nematode lifespan
  15. Model organism lifespan research
  16. A single-gene mutation doubles nematode lifespan
  17. The hallmarks of ageing
  18. Caenorhabditis elegans
  19. Caloric restriction
  20. NIA Interventions Testing Program
  21. A single-gene mutation doubles nematode lifespan
  22. The NIA Interventions Testing Program begins
  23. Evidence
  24. Supports the daf-2 lifespan doubling and its dependence on daf-16. V55 verification basis: not retrieved in this session.
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/atlas?object=EVT_LGV_KENYON_DAF2_1993&experience=EVT_LGV_KENYON_DAF2_1993