A single-gene mutation doubles nematode lifespan

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Cynthia Kenyon's laboratory reports that C. elegans carrying a mutation in daf-2, the insulin/IGF-1 receptor homologue, live more than twice as long as wild type and remain active, and that the extension requires the transcription factor daf-16. Ageing becomes a genetics problem, and the pathway turns out to be conserved into mammals.

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