The first senolytic drugs are identified
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Zhu, Kirkland and colleagues reason from the transcriptional profile of senescent cells that their survival depends on specific anti-apoptotic pathways, and identify dasatinib and quercetin as agents that kill senescent cells preferentially. The paper creates a drug class defined by a mechanism rather than by a disease.
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- Senolyticsconcerns
- Cellular senescenceconcerns
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Assembled from 20 blocks · 1 evidence · 11 related
- Story
- Zhu, Kirkland and colleagues reason from the transcriptional profile of senescent cells that their survival depends on specific anti-apoptotic pathways, and identify dasatinib and quercetin as agents that kill senescent cells preferentially. The paper creates a drug class defined by a mechanism rather than by a disease.
- Knowledge
- Cellular senescence
- Senolytics
- The first senolytic drugs are identified
- Connections
- Senolytics
- Cellular senescence
- Cellular senescence
- The missing surrogate endpoint for ageing
- The first senolytic drugs are identified
- Senolytics reach human patients for the first time
- The hallmarks of ageing
- Senolytics
- Human diploid cells are shown to have a finite replicative capacity
- The hallmarks of ageing are formalised
- The first senolytic drugs are identified
- Evidence
- Supports the definition of the senolytic drug class and the identification of dasatinib and quercetin as the first combination. V55 verification basis: not retrieved in this session.
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