Caloric restriction

Assembled from 24 blocks · 4 evidence · 17 related

1. Story
2. Sustained reduction of energy intake, typically by twenty to forty percent, without malnutrition. It is the oldest and most reproducible lifespan-extending intervention in laboratory animals: Clive McCay's group at Cornell reported in 1935 that restricted rats lived substantially longer than freely fed controls, and the result has been repeated across yeast, nematodes, flies and rodents for ninety years. It is also the clearest case of a result that did not survive translation cleanly. Two long-running rhesus macaque studies gave opposite answers — the Wisconsin National Primate Research Center reported reduced age-related mortality in 2009, the National Institute on Aging reported no significant survival benefit in 2012 — and the 2017 joint reanalysis attributed the difference to diet composition, age at onset and how the control animals were fed, meaning the Wisconsin controls may have been effectively overfed. In humans the CALERIE trial demonstrated feasibility and cardiometabolic benefit over two years, with no lifespan data and no prospect of any.
3. Knowledge
4. Model organism lifespan research
5. Caloric restriction
6. Connections
7. Model organism lifespan research
8. CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
9. Rapamycin
10. Caloric restriction extends rodent lifespan
11. Wisconsin reports that caloric restriction reduces age-related mortality in rhesus monkeys
12. The NIA rhesus study reports no significant survival benefit
13. CALERIE reports two-year results in humans
14. The hallmarks of ageing
15. Caenorhabditis elegans
16. Caloric restriction
17. NIA Interventions Testing Program
18. A single-gene mutation doubles nematode lifespan
19. The NIA Interventions Testing Program begins
20. Evidence
21. Supports the founding demonstration that dietary restriction extends rodent lifespan. V55 verification basis: not retrieved in this session.
22. Supports the Wisconsin finding of reduced age-related mortality under caloric restriction in rhesus macaques. V55 verification basis: not retrieved; cited here as one side of a documented disagreement rather than as a settled result.
23. Supports the NIA finding of no significant survival benefit from caloric restriction in rhesus macaques, contradicting the Wisconsin cohort. V55 verification basis: not retrieved; the 2017 joint reanalysis attributing the divergence to diet and control feeding is described but not separately cited.
24. Supports the feasibility, achieved-restriction shortfall and cardiometabolic outcomes of the only randomised trial of sustained caloric restriction in healthy non-obese humans. V55 verification basis: not retrieved; participant numbers and achieved restriction percentage are recalled and must be checked.