Leonard Hayflick

Assembled from 13 blocks · 1 evidence · 5 related

1. Story
2. American microbiologist (1928–2024) who, working with Paul Moorhead at the Wistar Institute in Philadelphia, showed in 1961 that normal human diploid cell strains undergo a finite number of population doublings — of the order of forty to sixty — before arresting. The result contradicted Alexis Carrel's widely believed claim that cultured chick heart cells could divide indefinitely, and it established that ageing has a cell-intrinsic component. Hayflick also derived the WI-38 cell strain used to produce several human vaccines. He remained, for six decades, one of the most consistent public sceptics of anti-ageing claims, arguing that ageing is the accumulation of molecular disorder rather than a programme and therefore not the kind of thing a drug can be expected to reverse.
3. Knowledge
4. Leonard Hayflick
5. Human diploid cells are shown to have a finite replicative capacity
6. Connections
7. Human diploid cells are shown to have a finite replicative capacity
8. Human diploid cells are shown to have a finite replicative capacity
9. Leonard Hayflick
10. Cellular senescence
11. Leonard Hayflick
12. Evidence
13. Supports the finite replicative capacity of normal human diploid fibroblasts and the refutation of indefinite culture. V55 verification basis: not retrieved in this session.