A single-gene mutation doubles nematode lifespan
Cynthia Kenyon's laboratory reports that C. elegans carrying a mutation in daf-2, the insulin/IGF-1 receptor homologue, live more than twice as long as wild type and remain active, and that the extension requires the transcription factor daf-16. Ageing becomes a genetics problem, and the pathway turns out to be conserved into mammals.
Historical — it happened, and the record is settled.
Subjects
- Cynthia Kenyon · person · United States · not located
- Caenorhabditis elegans · species · not located
- Model organism lifespan research · research programme · not located
Evidence
Partly verified — Core facts are sourced; some optional detail is deliberately absent.
A C. elegans mutant that lives twice as long as wild type
Supports the daf-2 lifespan doubling and its dependence on daf-16. V55 verification basis: not retrieved in this session.
Nature · 1993 · Partly verified
Kenyon C., Chang J., Gensch E., Rudner A. and Tabtiang R., Nature, vol. 366, 1993
Recorded on Cynthia Kenyon
- A single-gene mutation doubles nematode lifespan
- The NIA Interventions Testing Program begins
Related
Related because they share a subject in the Atlas — never because the text looks similar.