The NIA rhesus study reports no significant survival benefit
The National Institute on Aging's parallel rhesus macaque study reports in Nature that caloric restriction did not significantly improve survival, contradicting the Wisconsin result. A 2017 joint analysis attributes the divergence to differences in diet composition, age at onset and the feeding of the control animals, which at Wisconsin may have been effectively overfed. The disagreement is the most instructive episode in the field.
Uncertain — sources disagree, or the dating is contested. Stated here, not resolved.
Subjects
- Caloric restriction · process · not located
Evidence
Partly verified — Core facts are sourced; some optional detail is deliberately absent. This is the standing of the weakest source, not an average.
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Supports the NIA finding of no significant survival benefit from caloric restriction in rhesus macaques, contradicting the Wisconsin cohort. V55 verification basis: not retrieved; the 2017 joint reanalysis attributing the divergence to diet and control feeding is described but not separately cited.
Nature · 2012 · Partly verified
Mattison J.A. et al., Nature, vol. 489, 2012 (National Institute on Aging cohort)
Caloric restriction delays disease onset and mortality in rhesus monkeys
Supports the Wisconsin finding of reduced age-related mortality under caloric restriction in rhesus macaques. V55 verification basis: not retrieved; cited here as one side of a documented disagreement rather than as a settled result.
Science · 2009 · Partly verified
Colman R.J. et al., Science, vol. 325, 2009 (Wisconsin National Primate Research Center cohort)
Recorded on Caloric restriction
- Caloric restriction extends rodent lifespan
- Wisconsin reports that caloric restriction reduces age-related mortality in rhesus monkeys
- The NIA rhesus study reports no significant survival benefit
- CALERIE reports two-year results in humans
Related
Related because they share a subject in the Atlas — never because the text looks similar.