CALERIE reports two-year results in humans
The only randomised controlled trial of sustained caloric restriction in healthy non-obese adults reports its two-year outcomes: the intervention is feasible but achieved restriction falls well short of the twenty-five percent target, cardiometabolic risk markers improve, and bone density and lean mass decline. No lifespan inference is possible or claimed.
Historical — it happened, and the record is settled.
Subjects
- CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy) · research programme · United States · not located
- Caloric restriction · process · not located
Evidence
Partly verified — Core facts are sourced; some optional detail is deliberately absent.
A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity (CALERIE phase 2)
Supports the feasibility, achieved-restriction shortfall and cardiometabolic outcomes of the only randomised trial of sustained caloric restriction in healthy non-obese humans. V55 verification basis: not retrieved; participant numbers and achieved restriction percentage are recalled and must be checked.
The Journals of Gerontology, Series A · 2015 · Partly verified
Ravussin E. et al. for the CALERIE Study Group, The Journals of Gerontology Series A, 2015
Recorded on CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
Related
Related because they share a subject in the Atlas — never because the text looks similar.