Caloric restriction is reported to slow a pace-of-ageing measure
A reanalysis of stored CALERIE samples reports that two years of caloric restriction produced a small slowing of the DunedinPACE pace-of-ageing measure, without significant effects on first-generation epigenetic clocks. It is the closest thing to a randomised human result on a biological-ageing measure that exists — and it also demonstrates the problem, because nobody can yet say what a two or three percent change in that measure is worth in years of health.
Historical — it happened, and the record is settled.
Subjects
- CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy) · research programme · United States · not located
- Epigenetic clocks · model · not located
- The missing surrogate endpoint for ageing · physical criterion · not located
Evidence
Partly verified — Core facts are sourced; some optional detail is deliberately absent.
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
Supports the reported slowing of the DunedinPACE pace-of-ageing measure under caloric restriction, without significant effects on first-generation epigenetic clocks. V55 verification basis: not retrieved; the effect size is deliberately described qualitatively because the producer could not confirm the figure.
Nature Aging · 2023 · Partly verified
Waziry R. et al., Nature Aging, 2023
Recorded on CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy)
- The multi-tissue epigenetic clock is published
- CALERIE reports two-year results in humans
- Senolytics reach human patients for the first time
- Caloric restriction is reported to slow a pace-of-ageing measure
Related
Related because they share a subject in the Atlas — never because the text looks similar.