The hallmarks of ageing are formalised
López-Otín, Blasco, Partridge, Serrano and Kroemer publish nine candidate processes in Cell, each required to manifest with age, to accelerate ageing when worsened and to retard it when improved. The paper becomes the field's common vocabulary; a 2023 revision expands the list to twelve.
Historical — it happened, and the record is settled.
Subjects
- The hallmarks of ageing · model · not located
- Cellular senescence · phenomenon · not located
Evidence
Partly verified — Core facts are sourced; some optional detail is deliberately absent.
The Hallmarks of Aging (2013) and Hallmarks of aging: an expanding universe (2023)
Supports the hallmark framework, its three inclusion criteria and the expansion from nine to twelve hallmarks. V55 verification basis: neither paper was retrieved; the enumerated hallmark list must be checked against the originals.
Cell · 2013; 2023 · Partly verified
López-Otín C., Blasco M.A., Partridge L., Serrano M. and Kroemer G., Cell, 2013 and 2023
Recorded on The hallmarks of ageing
- Human diploid cells are shown to have a finite replicative capacity
- The hallmarks of ageing are formalised
- The first senolytic drugs are identified
Related
Related because they share a subject in the Atlas — never because the text looks similar.