The first senolytic drugs are identified
Zhu, Kirkland and colleagues reason from the transcriptional profile of senescent cells that their survival depends on specific anti-apoptotic pathways, and identify dasatinib and quercetin as agents that kill senescent cells preferentially. The paper creates a drug class defined by a mechanism rather than by a disease.
Historical — it happened, and the record is settled.
Subjects
- Senolytics · technology · not located
- Cellular senescence · phenomenon · not located
Evidence
Partly verified — Core facts are sourced; some optional detail is deliberately absent.
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Supports the definition of the senolytic drug class and the identification of dasatinib and quercetin as the first combination. V55 verification basis: not retrieved in this session.
Aging Cell · 2015 · Partly verified
Zhu Y. et al. (Kirkland laboratory), Aging Cell, 2015
Recorded on Senolytics
- Human diploid cells are shown to have a finite replicative capacity
- The hallmarks of ageing are formalised
- The first senolytic drugs are identified
- Senolytics reach human patients for the first time
Related
Related because they share a subject in the Atlas — never because the text looks similar.