Human diploid cells are shown to have a finite replicative capacity
Leonard Hayflick and Paul Moorhead report that normal human fibroblast strains stop dividing after a limited number of population doublings, overturning the belief that vertebrate cells in culture are intrinsically immortal. The arrested cells remain alive and metabolically active — the first description of what is now called cellular senescence.
Historical — it happened, and the record is settled.
Subjects
- Leonard Hayflick · person · United States · not located
- Cellular senescence · phenomenon · not located
Evidence
Partly verified — Core facts are sourced; some optional detail is deliberately absent.
The serial cultivation of human diploid cell strains
Supports the finite replicative capacity of normal human diploid fibroblasts and the refutation of indefinite culture. V55 verification basis: not retrieved in this session.
Experimental Cell Research · 1961 · Partly verified
Hayflick L. and Moorhead P.S., Experimental Cell Research, vol. 25, 1961
Recorded on Leonard Hayflick
- Human diploid cells are shown to have a finite replicative capacity
- The hallmarks of ageing are formalised
- The first senolytic drugs are identified
Related
Related because they share a subject in the Atlas — never because the text looks similar.