AlphaFold2 is assessed blind at CASP14

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At the fourteenth Critical Assessment of Structure Prediction, AlphaFold2 produced predictions against sequences whose experimentally determined structures had been solved but withheld, and was scored by independent assessors. The median domain GDT_TS is reported at 92.4, including on the free-modelling targets where no related structure was available to copy from — a level the assessment community described as competitive with experimental determination for most targets. The evidential design is the point: the claimant did not choose the targets, could not have trained on the answers, and did not do the scoring.

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